ガランギン
ガランギン（galangin）はフラボノールの一つ。コウリョウキョウ (Alpinia officinarum) [1]やHelichrysum aureonitens に高濃度に含まれるほか[2]、ナンキョウ (Alpinia galanga) の地下茎[3]やプロポリス[4]にも含まれている。in vitro 実験においては、抗細菌[5][6]・抗ウイルス作用[7]のほか、乳癌細胞の増殖を遅くすることも示されている[8][9]。
| ガランギン | |
|---|---|
| |
3,5,7-trihydroxy-2-phenylchromen-4-one | |
別称 Norizalpinin 3,5,7-Trihydroxyflavone 3,5,7-triOH-Flavone | |
| 識別情報 | |
| CAS登録番号 | 548-83-4 |
| PubChem | 5281616 |
| ChemSpider | 4444935 |
| UNII | 142FWE6ECS |
| 日化辞番号 | J1.607A |
| KEGG | C10044 |
| ChEBI | |
| ChEMBL | CHEMBL309490 |
| 410 | |
| |
| |
| 特性 | |
| 化学式 | C15H10O5 |
| モル質量 | 270.24 g mol−1 |
| 精密質量 | 270.052823 u |
| 密度 | 1.579 g/mL |
| 融点 |
214-215 °C, 487-488 K, 417-419 °F |
| 特記なき場合、データは常温 (25 °C)・常圧 (100 kPa) におけるものである。 | |
脚注
編集- ^ Ciolino HP, Yeh GC (1999). “The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor”. Br. J. Cancer 79 (9-10): 1340-1346. doi:10.1038/sj.bjc.6690216. PMC 2362711. PMID 10188874.
- ^ Afolayan AJ, Meyer JJ (1997). “The antimicrobial activity of 3,5,7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens”. Journal of Ethnopharmacology 57 (3): 177–181. doi:10.1016/s0378-8741(97)00065-2. PMID 9292410.
- ^ Kaur A, Singh R, Dey CS, Sharma SS, Bhutani KK, Singh IP (2010). “Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd.”. Indian J. Exp. Biol. 48 (3): 314-317. PMID 21046987.
- ^ Tosi, E; Re, E; Ortega, M; Cazzoli, A (2007). “Food preservative based on propolis: Bacteriostatic activity of propolis polyphenols and flavonoids upon Escherichia coli”. Food Chemistry 104: 1025. doi:10.1016/j.foodchem.2007.01.011.
- ^ Cushnie TPT, Lamb AJ (2006). “Assessment of the antibacterial activity of galangin against 4-quinolone resistant strains of Staphylococcus aureus”. Phytomedicine 13 (3): 187-191. doi:10.1016/j.phymed.2004.07.003. PMID 16428027.
- ^ Cushnie TPT, Lamb AJ (2005). “Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss”. Journal of Ethnopharmacology 101 (1-3): 243–248. doi:10.1016/j.jep.2005.04.014. PMID 15985350.
- ^ Afolayan AJ, Meyer JJ, Taylor MB, Erasmus D (1997). “Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens”. Journal of Ethnopharmacology 56 (2): 165–169. doi:10.1016/s0378-8741(97)01514-6. PMID 917497.
- ^ So, F. V.; Guthrie, N.; Chambers, A. F.; Moussa, M.; Carroll, K. K. (1996). “Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices”. Nutrition and Cancer 26 (2): 167–181. doi:10.1080/01635589609514473. PMID 8875554.
- ^ So, F.; Guthrie, N.; Chambers, A. F.; Carroll, K. K. (1997). “Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen”. Cancer Letters 112 (2): 127–133. doi:10.1016/S0304-3835(96)04557-0. PMID 9066718.