アグレプリストン

アグレプリストン
IUPAC命名法による物質名
	IUPAC名 (8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one;
臨床データ
販売名	Alizin
識別
CAS番号;	124478-60-0
ATCコード	G03XB90 (WHO)
PubChem	CID: 14153279
ChemSpider	16736563
UNII	0UT4JLE1CM
KEGG	D07096
ChEMBL	CHEMBL2103998
別名	RU-46534; RU-534; 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17α-[(Z)-propenyl]estra-4,9-dien-3-one
化学的データ
化学式	C29H37NO2
分子量	431.62 g·mol−1
	SMILES C/C=C\[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O;
	InChI InChI=1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1; Key:RTCKAOKDXNYXEH-FWSJOHTJSA-N;
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アグレプリストン（Aglepristone（INN））（商品名Alizin、旧開発コードネームRU-46534、RU-534）は、ミフェプリストンに関連する合成ステロイド系抗エストロゲン薬で、ヨーロッパのいくつかの国でVirbacから動物用医薬品として販売されている^[1]^[2]^[3]。特に妊娠中の動物の中絶薬として用いられる^[1]^[3]^[4] 。アグレプリストンはミフェプリストンと同様に、いくらかの抗糖質コルチコイド活性も有している^[5]^[6]。

脚注

^ ^a ^b “Pregnancy Loss in the Bitch and Queen”. Kirk's Current Veterinary Therapy XV. Elsevier Health Sciences. (1 December 2013). pp. 3009–. ISBN 978-0-323-22762-9
^ “Endocrine manipulation of reproduction.”. Applied Animal Endocrinology. CABI. (2010). pp. 207–. ISBN 978-1-84593-755-3
^ ^a ^b “Aglepristone”. Saunders Handbook of Veterinary Drugs: Small and Large Animal. Elsevier Health Sciences. (3 November 2010). pp. 120–. ISBN 978-1-4377-0192-0
^ “Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534)”. Journal of Reproduction and Fertility. Supplement. Advances in reproduction in dogs, cats and exotic carnivores: proceedings of the fourth International Symposium on Canine and Feline Reproduction, Oslo, Norway, 29 June-1 July 2000 57: 243–8. (2001). ISBN 978-0-906545-37-9. PMID 11787157.
^ “Induction of parturition with aglepristone in the Majorera goat”. Reproduction in Domestic Animals = Zuchthygiene 46 (5): 882–888. (October 2011). doi:10.1111/j.1439-0531.2011.01759.x. PMID 21320179.
^ “Hormonal changes in spontaneous and aglépristone-induced parturition in dogs”. Theriogenology 69 (4): 399–407. (March 2008). doi:10.1016/j.theriogenology.2007.10.008. PMID 18054071.

[BonaguraTwedt2013-1] “Pregnancy Loss in the Bitch and Queen”. Kirk's Current Veterinary Therapy XV. Elsevier Health Sciences. (1 December 2013). pp. 3009–. ISBN 978-0-323-22762-9

[Squires2010-2] “Endocrine manipulation of reproduction.”. Applied Animal Endocrinology. CABI. (2010). pp. 207–. ISBN 978-1-84593-755-3

[Papich2010-3] “Aglepristone”. Saunders Handbook of Veterinary Drugs: Small and Large Animal. Elsevier Health Sciences. (3 November 2010). pp. 120–. ISBN 978-1-4377-0192-0

[Concannon2001-4] “Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534)”. Journal of Reproduction and Fertility. Supplement. Advances in reproduction in dogs, cats and exotic carnivores: proceedings of the fourth International Symposium on Canine and Feline Reproduction, Oslo, Norway, 29 June-1 July 2000 57: 243–8. (2001). ISBN 978-0-906545-37-9. PMID 11787157.

[pmid21320179-5] “Induction of parturition with aglepristone in the Majorera goat”. Reproduction in Domestic Animals = Zuchthygiene 46 (5): 882–888. (October 2011). doi:10.1111/j.1439-0531.2011.01759.x. PMID 21320179.

[pmid18054071-6] “Hormonal changes in spontaneous and aglépristone-induced parturition in dogs”. Theriogenology 69 (4): 399–407. (March 2008). doi:10.1016/j.theriogenology.2007.10.008. PMID 18054071.

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IUPAC命名法による物質名

IUPAC名 (8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
臨床データ
販売名	Alizin
識別
CAS番号	124478-60-0
ATCコード	G03XB90 (WHO)
PubChem	CID: 14153279
ChemSpider	16736563
UNII	0UT4JLE1CM
KEGG	D07096
ChEMBL	CHEMBL2103998
別名	RU-46534; RU-534; 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17α-[(Z)-propenyl]estra-4,9-dien-3-one
化学的データ
化学式	C₂₉H₃₇N O₂
分子量	431.62 g·mol⁻¹
SMILES C/C=C\[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O
InChI InChI=1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1 Key:RTCKAOKDXNYXEH-FWSJOHTJSA-N
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アグレプリストン

関連記事

脚注